Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent

Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent

Abstract Purpose Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabelled ATMi to determine drug pharmacokinetics could assist patient selectio...

Full description

Bibliographic Details
Main Authors: Claudia Rose Fraser, Javier Ajenjo, Mathew Veal, Gemma Marie Dias, Chung Chan, Edward O’Neill, Gianluca Destro, Doreen Lau, Anna Pacelli, Veronique Gouverneur, Rebekka Hueting, Bart Cornelissen
Format: Article
Language:English
Published: SpringerOpen 2022-08-01
Series:EJNMMI Research
Subjects:
PET
ATM
Cancer
Molecular imaging
Online Access:https://doi.org/10.1186/s13550-022-00920-z

Internet

https://doi.org/10.1186/s13550-022-00920-z

Similar Items