Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile.

Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile.

Lipid metabolism in the ventromedial hypothalamus (VMH) has emerged as a crucial pathway in the regulation of feeding and energy homeostasis. Carnitine palmitoyltransferase (CPT) 1A is the rate-limiting enzyme in mitochondrial fatty acid β-oxidation and it has been proposed as a crucial mediator of...

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Bibliographic Details
Main Authors: Paula Mera, Joan Francesc Mir, Gemma Fabriàs, Josefina Casas, Ana S H Costa, Maria Ida Malandrino, José-Antonio Fernández-López, Xavier Remesar, Su Gao, Shigeru Chohnan, Maria Sol Rodríguez-Peña, Harald Petry, Guillermina Asins, Fausto G Hegardt, Laura Herrero, Dolors Serra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24819600/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24819600/?tool=EBI

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