Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks

Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks

Replication-dependent double-strand breaks (DSBs) are the main source of genomic instability as their inaccurate repair stimulates chromosomal rearrangements. In a recent work, we uncover a novel regulatory circuit that involves the Werner's syndrome helicase and CDK1, and that is essential for...

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Bibliographic Details
Main Authors: Valentina Palermo, Sara Rinalducci, Massimo Sanchez, Francesca Grillini, Annapaola Franchitto, Pietro Pichierri
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Molecular & Cellular Oncology
Subjects:
dna repair
end-resection
wrn protein
Online Access:http://dx.doi.org/10.1080/23723556.2016.1268243

Internet

http://dx.doi.org/10.1080/23723556.2016.1268243

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