TNF Receptor Type II as an Emerging Drug Target for the Treatment of Cancer, Autoimmune Diseases, and Graft-Versus-Host Disease: Current Perspectives and In Silico Search for Small Molecule Binders

TNF Receptor Type II as an Emerging Drug Target for the Treatment of Cancer, Autoimmune Diseases, and Graft-Versus-Host Disease: Current Perspectives and In Silico Search for Small Molecule Binders

There is now compelling evidence that TNF receptor type II (TNFR2) is predominantly expressed on CD4+Foxp3+ regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and plays a major role in the expansion and function of Tregs and MDSCs. Consequently, targeting of TNFR2 by either ant...

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Bibliographic Details
Main Authors: Faraz Shaikh, Jiang He, Pratiti Bhadra, Xin Chen, Shirley W. I. Siu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
TNF receptor type II
TNF
regulatory T cells
virtual screening
drug discovery
MM-PBSA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01382/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01382/full

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