Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized behaviorally by chorea, incoordination, and shortened lifespan and neuropathologically by huntingtin inclusions and neuronal degeneration. In order to facilitate studies of pathogenesis and therapeutics,...

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Main Authors: Yuji Tanaka, Shuichi Igarashi, Masayuki Nakamura, Juliette Gafni, Cameron Torcassi, Gabrielle Schilling, Danielle Crippen, Jonathan D. Wood, Akira Sawa, Nancy A. Jenkins, Neal G. Copeland, David R. Borchelt, Christopher A. Ross, Lisa M. Ellerby
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002160

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http://www.sciencedirect.com/science/article/pii/S0969996105002160

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