An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

Abstract The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair. Using a series of small molecule antagonists, we demonstrate a conformational equilibrium between an open and a pre-existin...

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Bibliographic Details
Main Authors: Gaofeng Cui, Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James R. Thompson, David J. Schuller, Alexandre Detappe, Michael T. Perfetti, Lindsey I. James, Stephen V. Frye, Dipanjan Chowdhury, Georges Mer
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41821-6

Internet

https://doi.org/10.1038/s41467-023-41821-6

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