Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies

Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies

BTK inhibitors, Bcl-2 inhibitors, and other targeted therapies have significantly improved the outcomes of patients with chronic lymphocytic leukemia (CLL). With increased survivorship, monitoring disease and deciphering potential mechanisms of resistance to these agents are critical for devising e...

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Bibliographic Details
Main Authors: David W. Woolston, Nathan D. Lee, Mazyar Shadman, Elena Latorre-Esteves, Xin Ray Tee, Jeanne Fredrickson, Brendan F. Kohrn, Chaitra Ujjani, Ashley Eckel, Brian Till, Min Fang, Jerald Radich, Ivana Bozic, Rosa Ana Risques, Cecilia C.S. Yeung
Format: Article
Language:English
Published: Ferrata Storti Foundation 2023-09-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/11262

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https://haematologica.org/article/view/11262

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