Reduction of Ca<sup>2+</sup> Entry by a Specific Block of KCa3.1 Channels Optimizes Cytotoxic Activity of NK Cells against T-ALL Jurkat Cells

Reduction of Ca<sup>2+</sup> Entry by a Specific Block of KCa3.1 Channels Optimizes Cytotoxic Activity of NK Cells against T-ALL Jurkat Cells

Degranulation mediated killing mechanism by NK cells is dependent on store-operated Ca<sup>2+</sup> entry (SOCE) and has optimum at moderate intracellular Ca<sup>2+</sup> elevations so that partial block of SOCE optimizes the killing process. In this study, we tested the effe...

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Bibliographic Details
Main Authors: Miguel Olivas-Aguirre, Laura Hadit Cruz-Aguilar, Igor Pottosin, Oxana Dobrovinskaya
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
acute lymphoblastic leukemia
Jurkat cells
NK cells
NK-92
NK-mediated killing
KCa3.1 channel
Online Access:https://www.mdpi.com/2073-4409/12/16/2065

Internet

https://www.mdpi.com/2073-4409/12/16/2065

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