Sustained Delivery of Chondroitinase ABC from Hydrogel System

Sustained Delivery of Chondroitinase ABC from Hydrogel System

In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial...

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Bibliographic Details
Main Authors: Filippo Rossi, Giuseppe Perale, Maurizio Masi, Gianluigi Forloni, Valentina Dell’Oro, Simonetta Papa, Cristina Rogora, Pietro Veglianese, Marco Santoro
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:Journal of Functional Biomaterials
Subjects:
chondroitinase ABC
hydrogels
drug delivery
spinal cord injury
Online Access:http://www.mdpi.com/2079-4983/3/1/199/

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