Comparative proteomics study of mitochondrial electron transport system modulation in SH-SY5Y cells following MPP+ versus 6-OHDA-induced neurodegeneration

Comparative proteomics study of mitochondrial electron transport system modulation in SH-SY5Y cells following MPP+ versus 6-OHDA-induced neurodegeneration

Abstract Parkinson’s disease (PD) is the second-most common neurodegenerative disease worldwide. Several studies have investigated PD for decades; however, the exact mechanism of disease development remains unknown. To study PD, SH-SY5Y cells are often treated with 6-hydroxydopamine (6-OHDA) or 1-me...

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Bibliographic Details
Main Authors: Ju-Yong Hyon, Hea Ji Lee, Sung Ho Yun, Eun Hee Han, Young-Ho Chung
Format: Article
Language:English
Published: SpringerOpen 2023-01-01
Series:Journal of Analytical Science and Technology
Subjects:
Parkinson’s disease
6-Hydroxydopamine
1-Methyl-4-phenylpyridinium
Mitochondrial dysfunction
Liquid chromatography–tandem mass spectrometry
Online Access:https://doi.org/10.1186/s40543-022-00365-y

Internet

https://doi.org/10.1186/s40543-022-00365-y

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