Pharmacokinetic Herb-Drug Interactions of Glipizide with <i>Andrographis paniculata</i> (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method

Pharmacokinetic Herb-Drug Interactions of Glipizide with <i>Andrographis paniculata</i> (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method

Co-administered medicinal herbs can modify a drug’s pharmacokinetics (PK), effectiveness, and toxicity. <i>Andrographis paniculata</i> (Burm. f.) ethanolic extract (APE) and andrographolide (AND) (a potent CYP2C9 inducer/inhibitor) can alter the pharmacokinetic parameters of glipizide (G...

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Bibliographic Details
Main Authors: Elza Sundhani, Agung Endro Nugroho, Arief Nurrochmad, Ika Puspitasari, Dita Amalia Prihati, Endang Lukitaningsih
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
herb–drug interactions
<i>Andrographis paniculata</i>
andrographolide
glipizide
Online Access:https://www.mdpi.com/1420-3049/27/20/6901

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https://www.mdpi.com/1420-3049/27/20/6901

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