hiPSC-Derived Epidermal Keratinocytes from Ichthyosis Patients Show Altered Expression of Cornification Markers

hiPSC-Derived Epidermal Keratinocytes from Ichthyosis Patients Show Altered Expression of Cornification Markers

Inherited ichthyoses represent a large heterogeneous group of skin disorders characterised by impaired epidermal barrier function and disturbed cornification. Current knowledge about disease mechanisms has been uncovered mainly through the use of mouse models or human skin organotypic models. Howeve...

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Bibliographic Details
Main Authors: Dulce Lima Cunha, Amanda Oram, Robert Gruber, Roswitha Plank, Arno Lingenhel, Manoj K. Gupta, Janine Altmüller, Peter Nürnberg, Matthias Schmuth, Johannes Zschocke, Tomo Šarić, Katja M. Eckl, Hans C. Hennies
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
autosomal recessive congenital ichthyosis
cornification
disease modelling
epidermal barrier function
induced pluripotent stem cells
trichothiodystrophy
Online Access:https://www.mdpi.com/1422-0067/22/4/1785

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https://www.mdpi.com/1422-0067/22/4/1785

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