Substantial heterogeneity of inflammatory cytokine production and its inhibition by a triple cocktail of toll-like receptor blockers in early sepsis

Substantial heterogeneity of inflammatory cytokine production and its inhibition by a triple cocktail of toll-like receptor blockers in early sepsis

IntroductionEarly sepsis is a life-threatening immune dysregulation believed to feature a “cytokine storm” due to activation of pattern recognition receptors by pathogen and danger associated molecular patterns. However, treatments with single toll-like receptor (TLR) blockers have shown no clinical...

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Bibliographic Details
Main Authors: Willem Buys, Alexandra Bick, Rabea J. Madel, Astrid M. Westendorf, Jan Buer, Frank Herbstreit, Carsten J. Kirschning, Jürgen Peters
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
whole blood assay
cytokine
early sepsis
hyperinflammation
immune modulation
toll-like receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1277033/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1277033/full

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