BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers

Most tumours associated with germline BRCA1/BRCA2 loss of function mutations respond to DNA damaging agents, however, some do not. Herein, the authors identify that a subset of breast/ovarian tumors retain a normal allele, which is associated with decreased overall survival after DNA damage-inducing...

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Bibliographic Details
Main Authors: Kara N. Maxwell, Bradley Wubbenhorst, Brandon M. Wenz, Daniel De Sloover, John Pluta, Lyndsey Emery, Amanda Barrett, Adam A. Kraya, Ioannis N. Anastopoulos, Shun Yu, Yuchao Jiang, Hao Chen, Nancy R. Zhang, Nicole Hackman, Kurt D’Andrea, Robert Daber, Jennifer J. D. Morrissette, Nandita Mitra, Michael Feldman, Susan M. Domchek, Katherine L. Nathanson
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00388-9

Internet

https://doi.org/10.1038/s41467-017-00388-9

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