Cancer Stem Cells: Secret of Failure
Although rapid responses or long disease free intervals can be retained in advanced stage cancer either by conventional treatment strategies or targeted therapies; cure is seldom if ever is obtained. Recent advances in tumor biology have succeeded in identifying a minor tumor cell subpopulation whic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayincilik
2016-08-01
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| Series: | Namık Kemal Tıp Dergisi |
| Subjects: | |
| Online Access: |
http://namikkemalmedj.com/archives/archive-detail/article-preview/cancer-stem-cells-secret-of-failure/40448
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| _version_ | 1828015871970246656 |
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| author | Selçuk Şeber Tarkan Yetişyiğit |
| author_facet | Selçuk Şeber Tarkan Yetişyiğit |
| author_sort | Selçuk Şeber |
| collection | DOAJ |
| description | Although rapid responses or long disease free intervals can be retained in advanced stage cancer either by conventional treatment strategies or targeted therapies; cure is seldom if ever is obtained. Recent advances in tumor biology have succeeded in identifying a minor tumor cell subpopulation which have extraordinary capabilities for treatment resistance against various treatment strategies utilizing chemotherapeutic agents and radiotherapy. These cells carry stem cell like properties such as ability to initiate tumor by themselves, self renewal and ability to differentiate into heterogeneous cancer cell lines. In this review , survival and metastatic capabilities of cancer stem cells (CSCs), resistance mechanisms against chemotherapeutic agents are summarized . Novel therapeutic strategies developing against these resilient cell group such as agents specifically designed for targeting survival pathways and intracellular metabolism of CSCs are also discussed. |
| first_indexed | 2024-04-10T10:26:10Z |
| format | Article |
| id | doaj.art-0f70331d60194e5e8bbef57c7ee91abd |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T10:26:10Z |
| publishDate | 2016-08-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-0f70331d60194e5e8bbef57c7ee91abd2023-02-15T16:21:22ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622016-08-014210110813049054Cancer Stem Cells: Secret of FailureSelçuk Şeber0Tarkan Yetişyiğit1 Namık Kemal University Faculty of Medicine, Department of Medical Oncology Namık Kemal University Faculty of Medicine, Department of Medical Oncology Although rapid responses or long disease free intervals can be retained in advanced stage cancer either by conventional treatment strategies or targeted therapies; cure is seldom if ever is obtained. Recent advances in tumor biology have succeeded in identifying a minor tumor cell subpopulation which have extraordinary capabilities for treatment resistance against various treatment strategies utilizing chemotherapeutic agents and radiotherapy. These cells carry stem cell like properties such as ability to initiate tumor by themselves, self renewal and ability to differentiate into heterogeneous cancer cell lines. In this review , survival and metastatic capabilities of cancer stem cells (CSCs), resistance mechanisms against chemotherapeutic agents are summarized . Novel therapeutic strategies developing against these resilient cell group such as agents specifically designed for targeting survival pathways and intracellular metabolism of CSCs are also discussed. http://namikkemalmedj.com/archives/archive-detail/article-preview/cancer-stem-cells-secret-of-failure/40448 cancer stem cell (csc)drug resistancetherapy |
| spellingShingle | Selçuk Şeber Tarkan Yetişyiğit Cancer Stem Cells: Secret of Failure Namık Kemal Tıp Dergisi cancer stem cell (csc) drug resistance therapy |
| title | Cancer Stem Cells: Secret of Failure |
| title_full | Cancer Stem Cells: Secret of Failure |
| title_fullStr | Cancer Stem Cells: Secret of Failure |
| title_full_unstemmed | Cancer Stem Cells: Secret of Failure |
| title_short | Cancer Stem Cells: Secret of Failure |
| title_sort | cancer stem cells secret of failure |
| topic | cancer stem cell (csc) drug resistance therapy |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/cancer-stem-cells-secret-of-failure/40448
|
| work_keys_str_mv | AT selcukseber cancerstemcellssecretoffailure AT tarkanyetisyigit cancerstemcellssecretoffailure |