Practical Recommendations for the Manipulation of Kinase Inhibitor Formulations to Age-Appropriate Dosage Forms

Practical Recommendations for the Manipulation of Kinase Inhibitor Formulations to Age-Appropriate Dosage Forms

Over 75 kinase inhibitors (KIs) have been approved for the treatment of various cancers. KIs are orally administrated but mostly lack pediatric age-appropriate dosage forms or instructions for dose manipulation. This is highly problematic for clinical practice in pediatric oncology, as flexible oral...

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Bibliographic Details
Main Authors: Emma C. Bernsen, Valery J. Hogenes, Bastiaan Nuijen, Lidwien M. Hanff, Alwin D. R. Huitema, Meta H. M. Diekstra
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
pediatric oncology
manipulation
formulation
kinase inhibitor
bioequivalence
Online Access:https://www.mdpi.com/1999-4923/14/12/2834

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https://www.mdpi.com/1999-4923/14/12/2834

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