Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer

Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer

Malic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through the production of pyruvate and reducing agent NAD(P)H. Recent studies have implicated the third and least well-characterized isoform, mitochondrial NADP+-dependent mal...

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Bibliographic Details
Main Authors: Tsehai A.J. Grell, Mark Mason, Aaron A. Thompson, Jose Carlos Gómez-Tamayo, Daniel Riley, Michelle V. Wagner, Ruth Steele, Rodrigo F. Ortiz-Meoz, Jay Wadia, Paul L. Shaffer, Gary Tresadern, Sujata Sharma, Xiaodi Yu
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Heliyon
Subjects:
Malic enzymes
X-ray crystallography
Single particle Cryo-EM
Allostery
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022036805

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http://www.sciencedirect.com/science/article/pii/S2405844022036805

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