Evolution of Multiple Domains of the HIV-1 Envelope Glycoprotein during Coreceptor Switch with CCR5 Antagonist Therapy

Evolution of Multiple Domains of the HIV-1 Envelope Glycoprotein during Coreceptor Switch with CCR5 Antagonist Therapy

ABSTRACT HIV-1 uses CD4 as a receptor and chemokine receptors CCR5 and/or CXCR4 as coreceptors. CCR5 antagonists are a class of antiretrovirals used to inhibit viral entry. Phenotypic prediction algorithms such as Geno2Pheno are used to assess CCR5 antagonist eligibility, for which the V3 region is...

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Bibliographic Details
Main Authors: Yueqi Du, Ellen Wu, Xiang Gao, Jie Zhang, John C. Martin, Bruce A. Rosa, Makedonka Mitreva, Lee Ratner
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
HIV
Envelope
CCR5
CXCR4
Coreceptor
CD4
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00725-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00725-22

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