Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

The Src-homology 3 domain of phosphatidyl-inositol-3-kinase (PI3K-SH3) is a model system for studying amyloid fibril formation. Here the authors present the 3.4 Å cryo-EM structure of the PI3K-SH3 amyloid fibril, which allows them to rationalize the effects of mutations on the kinetics of fibril for...

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Bibliographic Details
Main Authors: Christine Röder, Nicola Vettore, Lena N. Mangels, Lothar Gremer, Raimond B. G. Ravelli, Dieter Willbold, Wolfgang Hoyer, Alexander K. Buell, Gunnar F. Schröder
Format: Article
Language:English
Published: Nature Portfolio 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11320-8

Internet

https://doi.org/10.1038/s41467-019-11320-8

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