New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease

New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease

Down syndrome (DS) is a genetic disorder caused by a trisomy of the human chromosome 21 (Hsa21). Overexpression of Hsa21 genes that encode proteins and non-coding RNAs (ncRNAs) can disrupt several cellular functions and biological processes, especially in the heart. Congenital heart defects (CHDs) a...

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Bibliographic Details
Main Authors: Leslye Venegas-Zamora, Francisco Bravo-Acuña, Francisco Sigcho, Wileidy Gomez, José Bustamante-Salazar, Zully Pedrozo, Valentina Parra
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Genetics
Subjects:
Down syndrome
chromosome 21
congenital heart defects
hypertrophy
oxidative stress
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.792231/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.792231/full

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