New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease

New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease

Down syndrome (DS) is a genetic disorder caused by a trisomy of the human chromosome 21 (Hsa21). Overexpression of Hsa21 genes that encode proteins and non-coding RNAs (ncRNAs) can disrupt several cellular functions and biological processes, especially in the heart. Congenital heart defects (CHDs) a...

Full description

Bibliographic Details
Main Authors:	Leslye Venegas-Zamora, Francisco Bravo-Acuña, Francisco Sigcho, Wileidy Gomez, José Bustamante-Salazar, Zully Pedrozo, Valentina Parra
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Series:	Frontiers in Genetics
Subjects:	Down syndrome chromosome 21 congenital heart defects hypertrophy oxidative stress mitochondria
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2021.792231/full

Similar Items

Communication Between Cardiomyocytes and Fibroblasts During Cardiac Ischemia/Reperfusion and Remodeling: Roles of TGF-β, CTGF, the Renin Angiotensin Axis, and Non-coding RNA Molecules
by: Raúl Flores-Vergara, et al.
Published: (2021-09-01)

Endothelial activation impairs the function of small extracellular vesicles
by: Nicolas Herrera-Zelada, et al.
Published: (2023-03-01)

Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy
by: Sabrina Sepúlveda-Rivas, et al.
Published: (2021-06-01)

Determination of the sensitivity and secificity of hypertrophy of hyponychium as a new diagnodtic sing in down syndrome
by: M.H Daei-Parizi, et al.
Published: (1997-12-01)

Cytogenetic analysis of 1284 cases of Down syndrome
by: M.H Kariminejhad, et al.
Published: (1997-12-01)

Estrogen signaling as a bridge between the nucleus and mitochondria in cardiovascular diseases
by: Emanuel Guajardo-Correa, et al.
Published: (2022-09-01)

One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage
by: Beatrice Vione, et al.
Published: (2022-12-01)

Myristate induces mitochondrial fragmentation and cardiomyocyte hypertrophy through mitochondrial E3 ubiquitin ligase MUL1
by: César Vásquez-Trincado, et al.
Published: (2023-03-01)

A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21
by: Yasuhiro Kazuki, et al.
Published: (2020-06-01)

Generation of two induced pluripotent stem cell lines from patients with Down syndrome
by: Wenjuan Zhu, et al.
Published: (2023-10-01)

Prevalence and Patterns of Congenital Heart Defects and Other Major Non-Syndromic Congenital Anomalies Among Down Syndrome Patients: A Retrospective Study
by: Geleta BE, et al.
Published: (2024-04-01)

Partial trisomy 21 map: Ten cases further supporting the highly restricted Down syndrome critical region (HR‐DSCR) on human chromosome 21
by: Maria Chiara Pelleri, et al.
Published: (2019-08-01)

Down syndrome and consanguinity
by: Amir Akhavan Rezayat, et al.
Published: (2013-01-01)

Eruptive syringomas in Down’s syndrome
by: Mrinal Gupta
Published: (2018-04-01)

The birth of a child with Down’s syndrome. The impact of the first parent interview
by: Karla Adney Flores-Arizmendi, et al.
Published: (2014-07-01)

Mosaic Down syndrome and acute lymphoblastic B cell-leukemia. Case report
by: Parra-Baltazar, Isabel Mónica, et al.
Published: (2016-10-01)

Differential Effects of Oleic and Palmitic Acids on Lipid Droplet-Mitochondria Interaction in the Hepatic Cell Line HepG2
by: Andrea Eynaudi, et al.
Published: (2021-11-01)

Genómica del síndrome de Down
by: S Díaz Cuéllar, et al.
Published: (2016-09-01)

Distinct Molecular Signatures of Amyloid-Beta and Tau in Alzheimer’s Disease Associated with Down Syndrome
by: Shojiro Ichimata, et al.
Published: (2023-07-01)

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levelsResearch in context
by: Aoife Murray, et al.
Published: (2023-08-01)

Nystagmus in Down Syndrome – a Retrospective Notes Review
by: Dilys Oladiwura, et al.
Published: (2022-06-01)

Factores biológicos, psicológicos, y sociales que influyen en el Síndrome de Down
by: Diego-Peñaloza F, et al.
Published: (2020-06-01)

Micronucleated lymphocytes in parents of Down syndrome children
by: R.L. Silva-Grecco, et al.
Published: (2012-07-01)

Micronucleated lymphocytes in parents of Down syndrome children
by: R.L. Silva-Grecco, et al.
Published: (2012-07-01)

FREQUENCY OF CLINICAL FEATURES AND CYTOGENETIC DEFECTS IN DOWN SYNDROME DIAGNOSED AT AFIP
by: Saira Irum, et al.
Published: (2021-01-01)

Genetics and Molecular Basis of Congenital Heart Defects in Down Syndrome: Role of Extracellular Matrix Regulation
by: Nunzia Mollo, et al.
Published: (2023-02-01)

Down syndrome associated childhood myeloid leukemia with yet unreported acquired chromosomal abnormalities and a new potential adverse marker: dup(1)(q25q44)
by: Faten Moassass, et al.
Published: (2018-03-01)

The transcriptome profile of human trisomy 21 blood cells
by: Francesca Antonaros, et al.
Published: (2021-05-01)

Integrated Quantitative Transcriptome Maps of Human Trisomy 21 Tissues and Cells
by: Maria Chiara Pelleri, et al.
Published: (2018-04-01)

Overexpression of the Hsa21 Transcription Factor RUNX1 Modulates the Extracellular Matrix in Trisomy 21 Cells
by: Nunzia Mollo, et al.
Published: (2022-03-01)

A rare non-Robertsonian translocation involving chromosomes 15 and 21
by: Marcelo Razera Baruffi, et al.

Oral findings of Down syndrome children in Chennai city, India
by: Asokan Sharath, et al.
Published: (2008-01-01)

First Reported Case of Atypical Meningioma in an Individual with Down Syndrome
by: Rachel Vanderschelden, et al.
Published: (2022-04-01)

Genetic epidemiology of Down syndrome in Iran
by: Manoochehr Shariati
Published: (2005-02-01)

Análisis de la cinematografía del síndrome de Down
by: Jose Coronel-Hidalgo, et al.
Published: (2023-07-01)

Intracranial Calcification and Seizure with Down Syndrome: A Case Report
by: Nilshan Rai, et al.
Published: (2022-11-01)

Targeted treatment options for paediatric B-cell precursor acute lymphoblastic leukaemia patients with constitutional or somatic chromosome 21 alterations
by: Naomi Michels, et al.
Published: (2024-06-01)

Experimental setup for the identification of mitochondrial protease substrates by shotgun and top-down proteomics
by: Alice Di Pierro, et al.
Published: (2016-06-01)

Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome
by: Macarena Gómez de Salazar, et al.
Published: (2018-07-01)

Dental caries prevalence and treatment needs of Down syndrome children in Chennai, India
by: Asokan Sharath, et al.
Published: (2008-01-01)