Whole-body bioluminescence imaging of T-cell response in PDAC models

Whole-body bioluminescence imaging of T-cell response in PDAC models

IntroductionThe location of T-cells during tumor progression and treatment provides crucial information in predicting the response in vivo.MethodsHere, we investigated, using our bioluminescent, dual color, T-cell reporter mouse, termed TbiLuc, T-cell location and function during murine PDAC tumor g...

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Bibliographic Details
Main Authors: Roisin McMorrow, Giorgia Zambito, Alex Nigg, Karishma Lila, Thierry P. P. van den Bosch, Clemens W. G. M. Lowik, Laura Mezzanotte
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
bioluminescence imaging (BLI)
T-cell activation
PDAC - pancreatic ductal adenocarcinoma
immune checkpoint inhibitors (ICI)
tumor microenvironment (TME)
tumor-draining lymph nodes (TDLN)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1207533/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1207533/full

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