The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning.

The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning.

Pharmacologic studies with cyclooxygenase-2 (COX-2) inhibitors suggest that the late phase of ischemic preconditioning (PC) is mediated by COX-2. However, nonspecific effects of COX-2 inhibitors cannot be ruled out, and the selectivity of these inhibitors for COX-2 vs. COX-1 is only relative. Furthe...

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Bibliographic Details
Main Authors: Yiru Guo, Deepali Nivas Tukaye, Wen-Jian Wu, Xiaoping Zhu, Michael Book, Wei Tan, Steven P Jones, Gregg Rokosh, Shuh Narumiya, Qianhong Li, Roberto Bolli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3402528?pdf=render

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http://europepmc.org/articles/PMC3402528?pdf=render

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