The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning.
Pharmacologic studies with cyclooxygenase-2 (COX-2) inhibitors suggest that the late phase of ischemic preconditioning (PC) is mediated by COX-2. However, nonspecific effects of COX-2 inhibitors cannot be ruled out, and the selectivity of these inhibitors for COX-2 vs. COX-1 is only relative. Furthe...
| Main Authors: | , , , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Public Library of Science (PLoS)
2012-01-01
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| 叢編: | PLoS ONE |
| 在線閱讀: | http://europepmc.org/articles/PMC3402528?pdf=render |