Highly Variable Sialylation Status of Donor-Specific Antibodies Does Not Impact Humoral Rejection Outcomes

Highly Variable Sialylation Status of Donor-Specific Antibodies Does Not Impact Humoral Rejection Outcomes

Clinical outcome in antibody-mediated rejection (AMR) shows high inter-individual heterogeneity. Sialylation status of the Fc fragment of IgGs is variable, which could modulate their ability to bind to C1q and/or Fc receptors. In this translational study, we evaluated whether DSA sialylation influen...

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Bibliographic Details
Main Authors: Thomas Barba, Jean Harb, Stéphanie Ducreux, Alice Koenig, Virginie Mathias, Maud Rabeyrin, Eric Pouliquen, Antoine Sicard, Dimitri Chartoire, Emilie Dugast, Thierry Defrance, Emmanuel Morelon, Sophie Brouard, Valérie Dubois, Olivier Thaunat
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
antibody-mediated rejection
DSA
sialylation
glycosylation
solid organ transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00513/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00513/full

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