Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export.

Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export.

Vaccinia virus (VACV) uses microtubules for export of virions to the cell surface and this process requires the viral protein F12. Here we show that F12 has structural similarity to kinesin light chain (KLC), a subunit of the kinesin-1 motor that binds cargo. F12 and KLC share similar size, pI, hydr...

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Bibliographic Details
Main Authors: Gareth W Morgan, Michael Hollinshead, Brian J Ferguson, Brendan J Murphy, David C J Carpentier, Geoffrey L Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2829069?pdf=render

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http://europepmc.org/articles/PMC2829069?pdf=render

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