Colon-Targeted Trans-Cinnamic Acid Ameliorates Rat Colitis by Activating GPR109A

Colon-Targeted Trans-Cinnamic Acid Ameliorates Rat Colitis by Activating GPR109A

We designed colon-targeted trans-cinnamic acid (tCA) and synthesized its conjugates with glutamic acid (tCA-GA) and aspartic acid (tCA-AA). We evaluated the anti-colitic activity of colon-targeted tCA using a dinitrobenzenesulfonic acid-induced rat colitis model. The conjugates lowered the distribut...

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Bibliographic Details
Main Authors: Changyu Kang, Jaejeong Kim, Sanghyun Ju, Heeyeong Cho, Hyun Young Kim, In-Soo Yoon, Jin-Wook Yoo, Yunjin Jung
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
cinnamic acid
colon-specific drug delivery
inflammatory bowel disease
GPR109A
prodrug
Online Access:https://www.mdpi.com/1999-4923/15/1/41

Internet

https://www.mdpi.com/1999-4923/15/1/41

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