LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD4+ and CD8+) as well as a reduction of parasitism after challenge with Leishmania infantum plus salivary gland of Lutzomyia longipalpis

LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD4+ and CD8+) as well as a reduction of parasitism after challenge with Leishmania infantum plus salivary gland of Lutzomyia longipalpis

Abstract Background The development of a protective vaccine against canine visceral leishmaniasis (CVL) is an alternative approach for interrupting the domestic cycle of Leishmania infantum. Given the importance of sand fly salivary proteins as potent immunogens obligatorily co-deposited during tran...

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Bibliographic Details
Main Authors: Rodrigo Dian de Oliveira Aguiar-Soares, Bruno Mendes Roatt, Henrique Gama Ker, Nádia das Dores Moreira, Fernando Augusto Siqueira Mathias, Jamille Mirelle de Oliveira Cardoso, Nelder Figueiredo Gontijo, Oscar Bruna-Romero, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rodrigo Corrêa-Oliveira, Rodolfo Cordeiro Giunchetti, Alexandre Barbosa Reis
Format: Article
Language:English
Published: BMC 2014-02-01
Series:Parasites & Vectors
Subjects:
LBSapSal vaccine
Canine visceral leishmaniasis
Immunogenicity
Experimental challenge
Leishmania infantum
Saliva of Lutzomyia longipalpis
Online Access:https://doi.org/10.1186/1756-3305-7-61

Internet

https://doi.org/10.1186/1756-3305-7-61

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