Sequence motifs capable of forming DNA stem–loop structures act as a replication diode

Calculating peak‐height ratios between single‐nucleotide polymorphisms (SNP) alleles in sequencing chromatograms is a practical method for estimating their copy number proportions (CNPs). However, it is surprising that sequencing DNA from different directions might yield different results. We analyz...

Full description

Bibliographic Details
Main Authors: Andrey Shirak, Uri Seroussi, Elisha Gootwine, Eyal Seroussi
Format: Article
Language:English
Published: Wiley 2017-07-01
Series:FEBS Open Bio
Subjects:
Online Access:https://doi.org/10.1002/2211-5463.12233