S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease

S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease

Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by impaired motor coordination due to neurological defects and cerebellar dysfunction caused by the accumulation of cholesterol in endolysosomes. Besides the increase in lysosomal cholesterol, mitochondria are also enric...

Full description

Bibliographic Details
Main Authors: Leire Goicoechea, Sandra Torres, Laura Fàbrega, Mónica Barrios, Susana Núñez, Josefina Casas, Gemma Fabrias, Carmen García-Ruiz, José C. Fernández-Checa
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Redox Biology
Subjects:
Mitochondrial GSH
Neurodegeneration
Membrane fluidity
Antioxidants
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724001265

Internet

http://www.sciencedirect.com/science/article/pii/S2213231724001265

Similar Items