Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis

Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evid...

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Bibliographic Details
Main Authors: Ioannis Markakis, Ioannis Charitakis, Christine Beeton, Melpomeni Galani, Elpida Repousi, Stella Aggeloglou, Petros P. Sfikakis, Michael W. Pennington, K. George Chandy, Cornelia Poulopoulou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
T cells
potassium channels
Kv1.3
multiple sclerosis
patch clamp
calcium regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.714841/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.714841/full

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