Discordance between germline genetic findings and abnormal tumor immunohistochemistry staining of mismatch repair proteins in individuals with suspected Lynch syndrome

Discordance between germline genetic findings and abnormal tumor immunohistochemistry staining of mismatch repair proteins in individuals with suspected Lynch syndrome

Background and AimsTumor immunohistochemical staining (IHC) of DNA mismatch repair (MMR) proteins is often used to guide germline genetic testing and variant classification for patients with suspected Lynch syndrome. This analysis examined the spectrum of germline findings in a cohort of individuals...

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Bibliographic Details
Main Authors: Shujuan Pan, Hannah Cox, Jamie Willmott, Erin Mundt, Heidi Gorringe, Michelle Landon, Karla R. Bowles, Bradford Coffee, Benjamin B. Roa, Debora Mancini-DiNardo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
hereditary cancer syndrome
clinical genetic testing
cancer diagnosis
universal tumor screening
IHC – immunohistochemistry
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1069467/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1069467/full

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