Parallelized Latent Dirichlet Allocation Provides a Novel Interpretability of Mutation Signatures in Cancer Genomes

Parallelized Latent Dirichlet Allocation Provides a Novel Interpretability of Mutation Signatures in Cancer Genomes

Mutation signatures are defined as the distribution of specific mutations such as activity of AID/APOBEC family proteins. Previous studies have reported numerous signatures, using matrix factorization methods for mutation catalogs. Different mutation signatures are active in different tumor types; h...

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Bibliographic Details
Main Authors: Taro Matsutani, Michiaki Hamada
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Genes
Subjects:
cancer genome
mutation signature
Bayes modeling
latent Dirichlet allocation
Online Access:https://www.mdpi.com/2073-4425/11/10/1127

Internet

https://www.mdpi.com/2073-4425/11/10/1127

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