Multi-modal efficacy of a chimeric vesiculovirus expressing the Morreton glycoprotein in sarcoma

Multi-modal efficacy of a chimeric vesiculovirus expressing the Morreton glycoprotein in sarcoma

Vesiculoviruses are attractive oncolytic virus platforms due to their rapid replication, appreciable transgene capacity, broad tropism, limited preexisting immunity, and tumor selectivity through type I interferon response defects in malignant cells. We developed a synthetic chimeric virus (VMG) exp...

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Bibliographic Details
Main Authors: Chelsae R. Watters, Oumar Barro, Natalie M. Elliott, Yumei Zhou, Musa Gabere, Elizabeth Raupach, Alexander T. Baker, Michael T. Barrett, Kenneth H. Buetow, Bertram Jacobs, Mahesh Seetharam, Mitesh J. Borad, Bolni Marius Nagalo
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytics
sarcoma
Morreton virus
vesiculovirus
virotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000177

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http://www.sciencedirect.com/science/article/pii/S2372770523000177

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