Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the graft from human NK cell-mediated cytotoxicit...

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Bibliographic Details
Main Authors: Arthur A. Cross-Najafi, Kristine Farag, Abdulkadir Isidan, Wei Li, Wenjun Zhang, Zhansong Lin, Julia R. Walsh, Kevin Lopez, Yujin Park, Nancy G. Higgins, David K.C. Cooper, Burcin Ekser, Ping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
xenotransplantation
natural killer cells
immune tolerance
immune rejection
HLA-E
HLA-G
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1217809/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1217809/full

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