Promoter hypermethylation and comprehensive regulation of ncRNA lead to the down-regulation of ZNF880, providing a new insight for the therapeutics and research of colorectal cancer

Promoter hypermethylation and comprehensive regulation of ncRNA lead to the down-regulation of ZNF880, providing a new insight for the therapeutics and research of colorectal cancer

Abstract The human genome encodes more than 350 kinds of Krüppel-associated box (KRAB) domain-containing zinc-finger proteins (KZFPs), KRAB-type ZNF transcription factor family (KZNF) plays a vital role in gene regulatory networks. The KZNF family members include a large number of highly homologous...

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Bibliographic Details
Main Authors: Xiangqian Dong, Yinghui Zhang, Yang Sun, Qiong Nan, Maojuan Li, Lanqing Ma, Lei Zhang, Juan Luo, Yating Qi, Yinglei Miao
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Medical Genomics
Subjects:
KZFPs
Colorectal carcinoma
ZNF880
ceRNA
Online Access:https://doi.org/10.1186/s12920-023-01571-2

Internet

https://doi.org/10.1186/s12920-023-01571-2

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