Au@109Pd core–shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers: studies on the applicability of 109Pd/109mAg in vivo generator in combined β− auger electron therapy

Au@109Pd core–shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers: studies on the applicability of 109Pd/109mAg in vivo generator in combined β− auger electron therapy

Abstract Background In radionuclide therapy, to enhance therapeutic efficacy, an intriguing alternative is to ensure the simultaneous implementation of low- and high-LET radiation emitted from a one radionuclide. In the present study, we introduce the concept of utilizing 109Pd (T1/2 = 13.7 h) in th...

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Bibliographic Details
Main Authors: Nasrin Abbasi Gharibkandi, Kamil Wawrowicz, Agnieszka Majkowska-Pilip, Kinga Żelechowska-Matysiak, Mateusz Wierzbicki, Aleksander Bilewicz
Format: Article
Language:English
Published: SpringerOpen 2023-10-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
109Pd/109mAg in vivo generator
Radioimmunotherapy
Auger electron therapy
Nanotechnology
Online Access:https://doi.org/10.1186/s41181-023-00212-4

Internet

https://doi.org/10.1186/s41181-023-00212-4

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