Metformin Prevents Cocaine Sensitization: Involvement of Adenosine Monophosphate-Activated Protein Kinase Trafficking between Subcellular Compartments in the Corticostriatal Reward Circuit

Metformin Prevents Cocaine Sensitization: Involvement of Adenosine Monophosphate-Activated Protein Kinase Trafficking between Subcellular Compartments in the Corticostriatal Reward Circuit

Repeated cocaine exposure produces an enhanced locomotor response (sensitization) paralleled by biological adaptations in the brain. Previous studies demonstrated region-specific responsivity of adenosine monophosphate-activated protein kinase (AMPK) to repeated cocaine exposure. AMPK maintains cell...

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Bibliographic Details
Main Authors: Rachel Aruldas, Laura Buczek Orenstein, Sade Spencer
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
cocaine
sensitization
adenosine monophosphate-activated protein kinase
metformin
Online Access:https://www.mdpi.com/1422-0067/24/23/16859

Internet

https://www.mdpi.com/1422-0067/24/23/16859

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