STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice

STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice

Abstract Background Patients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING (stimulator of interferon genes), an innate immune modulator, is strongly implicated in pain pathogenesis via neuron-immune modulation. Given...

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Bibliographic Details
Main Authors: Nan Li, Chunyan Wang, Yuying Zhao, Yigang Wang, Tianyu Gao, Yonghao Yu, Guolin Wang, Linlin Zhang
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Neuroinflammation
Subjects:
STING
Opioid-induced itch
Chronic itch
TBK1
Type I interferon
Online Access:https://doi.org/10.1186/s12974-023-02783-0

Internet

https://doi.org/10.1186/s12974-023-02783-0

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