One-Step, Low-Cost, Operator-Friendly, and Scalable Procedure to Synthetize Highly Pure <i>N</i>-(4-ethoxyphenyl)-retinamide in Quantitative Yield without Purification Work-Up

One-Step, Low-Cost, Operator-Friendly, and Scalable Procedure to Synthetize Highly Pure <i>N</i>-(4-ethoxyphenyl)-retinamide in Quantitative Yield without Purification Work-Up

It is widely reported that <i>N</i>-(4-hydroxyphenyl)-retinamide or fenretinide (4-HPR), which is a synthetic amide of all-trans-retinoic acid (ATRA), inhibits in vitro several types of tumors, including cancer cell lines resistant to ATRA, at 1–10 µM concentrations. Additionally, studie...

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Bibliographic Details
Main Authors: Silvana Alfei, Guendalina Zuccari
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
<i>N</i>-(4-hydroxyphenyl)-retinamide
<i>N</i>-(4-ethoxyphenyl)-retinamide
one-step operator-friendly synthetic procedure
complete characterization
quantitative yield
high level of purity
Online Access:https://www.mdpi.com/1420-3049/27/11/3632

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https://www.mdpi.com/1420-3049/27/11/3632

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