Cardiomyocyte-specific disruption of the circadian BMAL1–REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart

Abstract Circadian disruption increases cardiovascular disease (CVD) risk, through poorly understood mechanisms. Given that small RNA species are critical modulators of cardiac physiology/pathology, we sought to determine the extent to which cardiomyocyte circadian clock (CCC) disruption impacts car...

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Bibliographic Details
Main Authors: Mary N. Latimer, Lamario J. Williams, Gobinath Shanmugan, Bryce J. Carpenter, Mitchell A. Lazar, Pieterjan Dierickx, Martin E. Young
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05537-z