The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

Summary: PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in homology-directed repair (HDR) is not well understood. Here, we identify the ubiquitin E3 ligase TRIP12 as negative regula...

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Bibliographic Details
Main Authors: Marco Gatti, Ralph Imhof, Qingyao Huang, Michael Baudis, Matthias Altmeyer
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
genome instability
endogenous DNA lesions
replication stress
cancer
BRCA mutations
PARP inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309700

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720309700

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