An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies

An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies

Abstract Targeted intracellular delivery of therapeutic proteins remains a significant unmet challenge in biotechnology. A promising approach is to leverage the intrinsic capabilities of bacterial toxins like diphtheria toxin (DT) to deliver a potent cytotoxic enzyme into cells with an associated me...

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Bibliographic Details
Main Authors: Shivneet K Gill, Seiji N Sugiman-Marangos, Greg L Beilhartz, Elizabeth Mei, Mikko Taipale, Roman A Melnyk
Format: Article
Language:English
Published: Springer Nature 2024-08-01
Series:EMBO Molecular Medicine
Subjects:
Immunotoxin
Intracellular Delivery
Diphtheria Toxin
Chelona Toxin
Antidrug Antibodies
Online Access:https://doi.org/10.1038/s44321-024-00116-z

Internet

https://doi.org/10.1038/s44321-024-00116-z

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