Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity

Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity

Obesity is a major risk factor for fatty liver disease. Here, using a forward genetic screen, the authors identify the gene GM4951 as a GTPase involved in lipid oxidation and development of NAFLD in mice.

Bibliographic Details
Main Authors: Zhao Zhang, Yu Xun, Shunxing Rong, Lijuan Yan, Jeffrey A. SoRelle, Xiaohong Li, Miao Tang, Katie Keller, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31812-4

Internet

https://doi.org/10.1038/s41467-022-31812-4

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