Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity
Obesity is a major risk factor for fatty liver disease. Here, using a forward genetic screen, the authors identify the gene GM4951 as a GTPase involved in lipid oxidation and development of NAFLD in mice.
Bibliographic Details
| Main Authors: |
Zhao Zhang,
Yu Xun,
Shunxing Rong,
Lijuan Yan,
Jeffrey A. SoRelle,
Xiaohong Li,
Miao Tang,
Katie Keller,
Sara Ludwig,
Eva Marie Y. Moresco,
Bruce Beutler |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-31812-4
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