Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity
Obesity is a major risk factor for fatty liver disease. Here, using a forward genetic screen, the authors identify the gene GM4951 as a GTPase involved in lipid oxidation and development of NAFLD in mice.
Main Authors: | Zhao Zhang, Yu Xun, Shunxing Rong, Lijuan Yan, Jeffrey A. SoRelle, Xiaohong Li, Miao Tang, Katie Keller, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-31812-4 |
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