Targeting miR‐126 disrupts maintenance of myelodysplastic syndrome stem and progenitor cells

Targeting miR‐126 disrupts maintenance of myelodysplastic syndrome stem and progenitor cells

Abstract Background Myelodysplastic syndrome (MDS) arises from a rare population of aberrant hematopoietic stem and progenitor cells (HSPCs). These cells are relatively quiescent and therefore treatment resistant. Understanding mechanisms underlying their maintenance is critical for effective MDS tr...

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Bibliographic Details
Main Authors: Huafeng Wang, Jie Sun, Bin Zhang, Dandan Zhao, Hongyan Tong, Herman Wu, Xia Li, Yingwan Luo, Dan Dong, Yiyi Yao, Tinisha McDonald, Anthony S. Stein, Monzr M. Al Malki, Flavia Pichiorri, Nadia Carlesso, Ya‐Huei Kuo, Guido Marcucci, Ling Li, Jie Jin
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Clinical and Translational Medicine
Subjects:
CpG‐antimiR‐126
HSPCs
miR‐126
myelodysplastic syndrome
transformation
Online Access:https://doi.org/10.1002/ctm2.610

Internet

https://doi.org/10.1002/ctm2.610

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