Reevaluating Rifampicin Breakpoint Concentrations for Mycobacterium tuberculosis Isolates with Disputed rpoB Mutations and Discordant Susceptibility Phenotypes

Reevaluating Rifampicin Breakpoint Concentrations for Mycobacterium tuberculosis Isolates with Disputed rpoB Mutations and Discordant Susceptibility Phenotypes

ABSTRACT In this study, rifampicin resistance breakpoints based on MICs of disrupted rpoB mutants of Mycobacterium tuberculosis (MTB) were explored using the Mycobacteria Growth Indicator Tube (MGIT) system and microplate alamarBlue assay (MABA). Sixty-one MTB isolates with disputed low-level rifamp...

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Bibliographic Details
Main Authors: Wei Wang, Rongmei Liu, Cong Yao, Fengmin Huo, Yuanyuan Shang, Xuxia Zhang, Yufeng Wang, Zhongtan Xue, Liping Ma, Yu Pang
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
mutations
Mycobacterium tuberculosis
rifampicin
susceptibility
rpoB
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02087-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.02087-21

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