Upregulation of PD-1/PD-L1 and downregulation of immune signaling pathways lead to more severe visceral leishmaniasis in undernutrition mice

Upregulation of PD-1/PD-L1 and downregulation of immune signaling pathways lead to more severe visceral leishmaniasis in undernutrition mice

Abstract Background Leishmaniasis is mainly prevalent in tropical and subtropical developing countries, where chronic undernutrition often co-exists. Undernutrition is reported to promote the progression of leishmaniasis, but its immune mechanisms have not been fully elucidated. Methods To simulate...

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Bibliographic Details
Main Authors: Jinlei He, Jianhui Zhang, Xuechun Liao, Yuying Xiao, Jiao Li, Zhiwan Zheng, Dali Chen, Jianping Chen
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Parasites & Vectors
Subjects:
Leishmaniasis
PD-1
PD-L1
Undernutrition
RNA-seq
Online Access:https://doi.org/10.1186/s13071-023-06018-2

Internet

https://doi.org/10.1186/s13071-023-06018-2

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