The Search for Covalently Ligandable Proteins in Biological Systems

The Search for Covalently Ligandable Proteins in Biological Systems

This commentary highlights the recent article published in Nature, June 2016, titled: “Proteome-wide covalent ligand discovery in native biological systems”. They screened the whole proteome of different human cell lines and cell lysates. Around 700 druggable cysteines in the whole proteome were fou...

Full description

Bibliographic Details
Main Authors: Syed Lal Badshah, Yahia Nasser Mabkhot
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Molecules
Subjects:
fragment-based ligand discovery
covalent binding ligands
druggable cysteines
isotopic tandem orthogonal proteolysis‒activity-based protein profiling
methyl transferase
protease caspase enzyme
Online Access:http://www.mdpi.com/1420-3049/21/9/1170

Internet

http://www.mdpi.com/1420-3049/21/9/1170

Similar Items